Cannabis sativa, commonly referred to as cannabis, is a plant that contains over 60 compounds known as cannabinoids. Among these compounds is cannabidiol (CBD) which, unlike tetrahydrocannabinol (THC), doesn’t produce psychoactive effects.

CBD has become a widely used product over the past several years. The FDA has only approved it in one product to treat seizures associated with Lennox-Gastaut syndrome, Dravet syndrome or tuberous sclerosis complex in patients one year or older. However, research is examining CBD’s impact on various ailments that are psychiatric, neurodegenerative, inflammatory, and cancerous in nature.1

Some studies indicate that CBD oil can effectively treat stress and anxiety. It does so by acting on the endocannabinoid system, a neural network that is part of the central nervous system, which plays a role in modulating cognitive and physiological functions.2 Here’s what the findings on CBD oil for stress and anxiety have shown so far. 

Stress-Related Benefits of CBD Oil 

CBD shows promise in alleviating symptoms of anxiety disorders. In a 2020 review, researchers examined a series of clinical trials, a case series, and a case report.

Optimal Dosage for Stress Relief

Doses varied widely from between 6 mg and 400 mg, participants showed improved clinical outcomes in various anxiety assessment scales. cbd was generally well tolerated.3 

Symptom Relief in Young People

One trial noted that CBD could lead to symptom relief in young people with treatment-resistant moderate-to-severe anxiety. Thirty-one participants between the ages of 12 and 25 took CBD for twelve weeks, titrating it to a maximum dose of 800 mg. At the conclusion of the study, participants reported significant improvements in anxiety and overall functioning, with no serious adverse effects reported.4  

CBD can also improve certain measures of acute stress, such as participants’ heart rate variability (HRV)—a physiological marker of stress.

Of note, participants who went into the study believing that CBD could alleviate their stress did indeed have greater changes in HRV.5 

Possible Side Effects

Although most people assume that CBD is safe, almost half of those who try it experience side effects. These may include:6

• Drowsiness
• Dizziness
• Anxiety
• Nausea
• Mood changes (e.g., depressed mood)
• Appetite changes
• Diarrhea 
• Infections
• Elevated liver enzymes
• Possible impairment of male fertility

Specific side effects and their intensity can vary from person to person based on the amount of CBD taken. It’s best to start with a smaller dose and increase it as you determine your tolerance. 

Is Cannabidiol (CBD) Addictive?

Contraindications

There are some cases in which you would want to refrain from consuming CBD oil.

If You Have Allergies

Individuals with allergies to cannabidiol or sesame oil should refrain from using CBD. 

A History of Drug and Alcohol Use Disorders

Additionally, those with a history of drug or alcohol abuse should proceed with caution with CBD. Physicians can assess the risks and benefits of using CBD for individuals with prior or ongoing substance use.1

If You Already Take Benzodiazepines

Furthermore, those who take benzodiazepines to manage symptoms of a mental health condition may need to titrate down on their medications prior to taking CBD. Simultaneous use of CBD and benzodiazepines may cause significant sedation.7 

Always Speak to Your Doctor First Before Trying a New Drug

Individuals who take CBD with certain medications can experience liver damage. If you are currently taking medications, check with your doctor before starting CBD to ensure there aren’t any potential drug reactions.8 

If you are experiencing adverse effects, it’s important to seek medical care immediately. 

15 february 2019